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Cyclic Tetrapeptides from Marine Bacteria Associated with the Seaweed Diginea sp. and the Sponge Halisarca Ectofibrosa

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dc.contributor.author Chutiwan Dechsakulwatana
dc.contributor.author Wimolpun Rungprom
dc.contributor.author Eric R.O. Siwu
dc.contributor.author Lynette K. Lambert
dc.contributor.author Michael C. Barden
dc.contributor.author Udom Kokpol
dc.contributor.author Joanne T. Blanchfield
dc.contributor.author Masaki Kita
dc.contributor.author Mary J. Garson
dc.contributor.other Institute of Marine Science en
dc.date.accessioned 2019-03-25T09:14:48Z
dc.date.available 2019-03-25T09:14:48Z
dc.date.issued 2008
dc.identifier.uri http://dspace.lib.buu.ac.th/xmlui/handle/1234567890/2382
dc.description.abstract A Pseudomonas sp. was cultured which was associated with the Japanese seaweed Diginea sp. Crude extracts prepared from this bacterial culture were found to inhibit the growth of other marine bacterial strains. From this bacterial culture, two new peptides cyclo-[phenylalanyl-prolyl-leucyl-prolyl] (3) and cyclo-[isoleucyl-prolyl-leucyl-alanyl] (4) have been isolated together with two known peptides (1) and (2). The crude extract from a culture of Pseudoalteromonas sp. associated with the Thai sponge Halisarca ectofibrosa was found to inhibit the growth of Bacillus subtilis and Vibrio anguillarum. Isolation studies yielded a fraction containing two peptides that were identified as cyclo-[phenylalanyl-leucyl]2 (5) and cyclo-[leucyl-isoleucyl]2 (6) by means of LC-MS and 2D NMR data. Absolute stereochemistry was confirmed by the synthesis of cyclo-[l-phenylalanyl-l-leucyl]2. Peptides (1)–(3) were also isolated from this bacterial strain. None of the individual peptides isolated in this study showed antibiotic activity. en
dc.language.iso eng th_TH
dc.subject Diginea th_TH
dc.subject Halisarca th_TH
dc.subject NMR th_TH
dc.subject Peptides th_TH
dc.subject Sponges th_TH
dc.title Cyclic Tetrapeptides from Marine Bacteria Associated with the Seaweed Diginea sp. and the Sponge Halisarca Ectofibrosa en
dc.type บทความวารสาร th_TH
dc.issue 14
dc.volume 64
dc.year 2008
dc.journal Tetrahedron
dc.page 3147–3152.

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